| Bioactivity | 1,1′-Ethylidenebis[L-tryptophan] is an impurity in the synthesis of L-tryptophan. 1,1′-Ethylidenebis[L-tryptophan] promotes the proliferation of eosinophilic leukemia cells, induces the release of eosinophil cationic protein from eosinophils, and stimulates T cells to produce IL-5. 1,1′-Ethylidenebis[L-tryptophan] (40 µg/kg) can induce fascia thickening, mast cell infiltration, and fibrosis in adipose and subcutaneous muscle tissues in mice. 1,1′-Ethylidenebis[L-tryptophan] can be used in immunology and inflammation research[1][2][3]. |
| CAS | 132685-02-0 |
| Formula | C24H26N4O4 |
| Molar Mass | 434.49 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yamaoka KA, et al. 1,1'-Ethylidenebis(tryptophan) (Peak E) induces functional activation of human eosinophils and interleukin 5 production from T lymphocytes: association of eosinophilia-myalgia syndrome with a L-tryptophan contaminant. J Clin Immunol. 1994 Jan;14(1):50-60. [2]. Trucksess MW. Separation and isolation of trace impurities in L-tryptophan by high-performance liquid chromatography. J Chromatogr. 1993 Feb 5;630(1-2):147-50. [3]. Love LA, et al. Pathological and immunological effects of ingesting L-tryptophan and 1,1'-ethylidenebis (L-tryptophan) in Lewis rats. J Clin Invest. 1993 Mar;91(3):804-11. |
1,1′-Ethylidenebis[L-tryptophan]
CAS: 132685-02-0 F: C24H26N4O4 W: 434.49
1,1′-Ethylidenebis is an impurity in the synthesis of L-tryptophan. 1,1′-Ethylidenebis promotes the proliferation of e
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